where C is the annual mean observed concentration of the NPS pollutants in the outlet of the sub-watershed (g/L), Q is the annual total stream flow measured in the outlet (m3), and k is the loss coefficient of the NPS pollutants in the sub-watershed.
Accuracy was expressed as the percent deviation of the mean observed concentration from the theoretical value, which should not exceed 15%, except at the LOQ (20%).
The ratio of geometric means of observed concentrations and expected contractions was 0.52 (95% CI = 0.46 to 0.60).
Mean maximum observed concentration (Cmax) and AUC from time of dosing to time of last observation (AUC(0 t)) were calculated and expressed as a ratio (co-administration/alone). Principal efficacy end points were objective response rates, time to tumour progression (TTP) and survival.
First, AUC inf could be slightly underestimated due to the absence of any sample before 2.7 hours post-ingestion and between 2.7 and 10.5 hours, as the mean maximal observed concentration has been previously reported between 2.5 and 4.4 hours post-ingestion [ 29].
Mean observed bevacizumab concentrations were generally less than those predicted from simulations with overlapping 95%-confidence intervals at each of the assessed time points.
Subjects who carried CYP2B6*1/*1 or *1/*6 genotypes had EFV PK exposures similar to those in the EFV product label, which shows a mean AUC(0– τ ) of 184 μM·h (58.1 μg·h/mL), mean Cmax of 12.9 μM (4.07 μg/mL) and mean minimum observed plasma concentration (Cmin) of 5.6 μM (1.77 μg/mL) [ 12].
Differences in folate status may partially explain the higher tHcys concentrations in our population; in 4- to 11-year-old participants in NHANES III, mean plasma folate levels measured were 19.9 nmol/L (Pfeiffer et al. 2007), substantially higher than the mean concentrations observed in this study (12.8 nmol/L).
For influenza A virus, both the positive rate (the number of positive samples divided by the number of all samples) and mean concentration were higher during ADS episodes than during background days at both monitoring stations (Table 3), with a significant difference in mean concentrations observed at the Wan-Li station on the northern tip of Taiwan (p < 0.05, Mann-Whitney U-test).
Condensed tannin concentration in control F2 plants ranged from 20·1 mg g−1 (less than the mean concentration found in S. sericea leaves) to 345·1 mg g−1 (greater than the mean concentration observed in S. eriocephala leaves; Fig. 1B).
