To evaluate this issue, we examined the correlations of expression levels in breast tumors and normal tissue using publically available data from The Cancer Genome Atlas 3. Of the 196 genes in our panel the mean normal-tumor correlation is a modestly positive 0.113.
I mean, normal people do that.
Oops, I mean "normal" job.
The red bold line plots the mean spectrum for normal, tumor, and necrosis, respectively.
The frequency of positive cases was obtained by comparing the mean normal array with each individual tumor or cell line array.
Mice were weighed weekly and were sacrificed when the mean normal body weigth decreased <25% or when mice developped tumor side effects like ascites or reduced general condititon.
With the LINE1-1 assay, the mean primary tumor PMR was 65.5%, while the mean normal PMR was 90.0% (p-value = 6.7×10−8 using a paired t-test).
Mean tumor levels of ctHHb, ctO2Hb, and ctH2O are nearly two-fold greater than normal; tumor %lipid is reduced by approximately 45%, and scatter power increases by about 40% in tumors.
zero mean normal random variables.
That can mean the tumor but also certain normal cells, causing side effects like hair loss, nausea, diarrhea and anemia.
The means for normal and tumor tissue were compared using an unpaired Welch's t-test.
