Sentence examples for mean mutation frequency from inspiring English sources

In untreated mice the mean mutation frequency (Mf) in cauda spermatozoa (29.7±3.7×10−6, n = 6) was significantly lower than that of the liver (58.5±1.9×10−6, n = 3; p = 0.024 (Mann-Whitney), Figures 3 and 4, and Tables 1 and 2).

The principal purpose of this mean is to link the mutation rate of replication to the mean mutation frequency in the progeny population, so the appropriate measure is to average over virions, not infected cells.

Specifically, the absence of mutations in many short and/or imperfect loci, as well as the fact that for five markers only one mutation has been identified, do not allow us to use these results in deriving a mean mutation frequency.

Interesting to note that the unselected TEM-1 libraries of Zaccolo and Gherardi contained a mean mutation frequency of 8.2 and 27.2 substitutions per gene length, however, clones selected on the basis of cefotaxine resisitance showed only 1 11 mutations at the DNA level.

Mean mutation frequencies of L- and H-chain genes were 3% and 8%, respectively.

In conclusion, although these gene-specific mutation rates are higher than the mean mutation frequencies for this length of repeats they do not reach statistical significance and prediction about positive Selective Target Genes in MSI-H tumorigenesis is not feasible.

DOI: http://dx.doi.org/10.7554/eLife.02001.019 The top or bottom strand location of the lesions differentially affected their mutagenic effect: repair of top strand T/Gs generated ∼fourfold more mutated episomes than the 0 MM control (respective mean percent mutation frequency 0.107 vs 0.025).

In HNPCC patients aged < 49 years the mean stem cell mutation frequency was significantly lower than in the slightly younger group of patients with Crohn's disease (0.8 +/- 0.9 x 10 -4) vs 3.5 +/- 3.3 x 10 -4), P < 0.01), probably reflecting an increased mutation rate relating to chronic mucosal damage in Crohn's disease.

It is not possible to compare these two data, because the mutation frequency in the present work means changes incorporated in a population during a point in time (nucleotide/site/year), on the other hand, the value identified in Avsunviroidae means a mutation rate per site and replication cycle.

Intracellular CFU and PMBr mutation frequency data are presented as the means ± standard error of the mean (SEM).

These data, combined with refined analyses of single-locus variation frequencies in a population-based dataset of >2700 isolates, lead to an estimate of mean mutation rate per year and per locus of 10−4 [25].