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The mean motor threshold for participants of Experiment 1 was 37.6±1.4% of the maximum stimulator output.
The mean motor threshold (RMT) was 53.3% (SD 7.15) of the maximum stimulator output intensity; hence mean stimulation intensity for the experiment was 63.9% (SD 8.62).
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The average motor threshold was 60% of the maximum stimulator output (range 39 75%).
Individual TMS resting motor thresholds were obtained in a separate session, via stimulation over the right M1 'hotspot' for inducing a visible twitch of the first dorsal interosseus (mean resting motor threshold with conventional TMS coil 56 ± 10% of maximal stimulator output; or with the non-ferrous MR-compatible coil that had a longer cable 67±10%0% of maximal output).
This intensity was 130% of the individual motor threshold [21] (mean intensity output in PAS-25 = 53.2±2.71; mean intensity output in PAS-50 = 53.2±2.60) and it was kept constant throughout the session.
As stimulus intensity increased from 60 to 150% resting motor threshold, the mean cortical silent period duration increased from 0 to 212.8 ± 6.9 ms in patients with acquired neuromyotonia and was significantly different to patients with ALS, where it was reduced (ALS 0 181.1 ± 4.3 ms; controls 208.2 ± 3.1 ms, F = 13.2, P < 0.0001).
Although a one-side reduction of the H-reflex amplitude can be noted in Figure 3A and 3B, there was no significant difference (t = 1.15, p = 0.25) in the mean H-reflex amplitude measured at motor threshold between controls and Group 1 patients (see also Table 1).
No side-to-side differences were observed in motor threshold or torque measurements; therefore, mean values of left- and right-sided data were used in the analysis.
Comparing Standard and Reversed TMS (Fig. 3), the motor threshold was higher for Reversed TMS (Fig8 coil: mean difference = 10.7, standard deviation (SD) = 4.7; Circ coil: mean difference = 11.3, SD = 3.1).
In 5 subjects (5 men; range 21 43, mean age 28.4±8.6), point h was stimulated at 110% of resting motor threshold to investigate the possibility of current diffusion to the primary motor cortex.
Resting motor threshold.
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