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Among the 20 % who did report sickness absence in our study, the mean monthly frequency was as high as 15 days/person.
Clear evidence from randomized controlled trials powered on this endpoint has demonstrated that topiramate 100 mg/day or 200 mg/day is more effective than placebo in reducing the mean monthly frequency of migraines.
A post-hoc pooled analysis of patients with migraine with aura enrolled in three double-blind clinical trials reported that topiramate (target dose 100 mg/day) reduced the mean monthly frequency of aura significantly more than placebo (P=0.020) (Silberstein et al. 2005b).
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Mean monthly SSC and mean monthly SSL provide a good exponential relationship with mean monthly air temperature.
The calibrated coefficient values are determined by matching calculated mean monthly Hamon PET to mean monthly free-water surface evaporation.
Their mean monthly income was 1510.6 Ethiopian birr (ETB).
Their family mean monthly income was Ethiopian birr (ETB) 1801.
In this study, the mean monthly migraine frequency reduction seems less evident when compared to the previous study [10], probably because migraine frequency at baseline was lower (range 2 9 in the ITT topiramate population) and children with chronic migraine were excluded.
In subjects who had previously taken other migraine preventives, treatment with topiramate100 mg/day and 200 mg/day significantly reduced mean monthly migraine frequency.
This seems a well-performed trial in which the mean monthly migraine frequency reduction is clearly evident in the topiramate-treated group.
There was a statistically significant decrease in the mean monthly migraine frequency in the topiramate group as compared with the placebo group (11.9 vs. 5.9 days, P = 0.025).
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