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In contrast to MLCK, ROCK inhibition enhanced mean migration speeds by ∼25% relative to controls.
The contributions of individual α-actinin isoforms to glioma motility were quantified by calculating and comparing mean migration speeds for each condition (Figure 2).
The cells' mean migration speeds were measured by tracking the displacement of the moving cell from frame to frame in a time-lapse experiment.
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These results were consistent with the mean migration speed.
Parameter values specified the mean migration speed of cells or clusters in grid units per simulation cycle.
The mean migration speed was estimated to range from 360 μm/day (Kim et al. 2004) to 50 80 μm/h (Zhang et al. 2003).
There may also be a period of delayed migration in steelhead smolts prior to the start of seaward migration, which would explain the slower average migration speeds downstream.
Average migration speed was calculated from the average distance traveled and the time elapsed between images.
Finally, to ensure that mean arrival probabilities and migration speeds did not significantly differ with simulations greater than 10 000 individuals, we also simulated populations of 30 000 individuals.
We also observed no significant changes in the mean ALC diameters when we doubled cell migration speed: the mean ALC diameter at any cell density remained virtually unchanged.
Table 4 Predicted migration costs System Migration Size Mean migration duration (Std Dev).
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