Sentence examples for mean methylation difference from inspiring English sources

In the case of BOP analysis, BOPs can be ranked on the basis of a user-defined minimum mean methylation difference between adjacent CpG probes.

Next, we focused on the differentially methylated CpGs with the largest mean methylation difference between fusion-negative and fusion-positive PCa (≥25%%).

The relationship between the mean methylation difference and the log2 fold change for those 162 genes is shown in Figure 4A (Pearson correlation coefficient = −0.75 with 95% confidence interval: −0.81 to −0.68 and regression p-value<2.2e-16 p-value<2.2e-16 p-value<2.2e-16

Of the 27K significant CpG sites, 3103 had a mean methylation difference of at least 10%% between T2E subtypes (Additional file 1).

A total of 18 256/12 339 CpG sites showed statistical significance with adjusted P-values <0.05/0.01 and ⩾0.12 mean methylation difference between BPH and PCa.

Many of the DMRs (41%) show little variability in DNA methylation within the population – we define these as very low range DMRs (less than 0.2 mean methylation difference across all strains) and low range (between 0.2 and 0.4 mean methylation difference across all strains).

The authors [ 82] found no differences in DNA methylation of the five MZ twin pairs for rheumatoid arthritis and dermatomyositis, but they found a set of 49 genes differentially methylated in SLE discordant twins with absolute mean methylation differences >0.1.

The 24 CpGs were similarly differentially methylated by T2E status in TCGA (P values ≤5.44E−37); mean methylation differences between patient groups for these CpGs ranged from 24 to 49%% (mean = 36%%).

Age group (young or old) was added to the models as a random effect to test for differences in variation or discordance and as an extra fixed effect, replacing age, to estimate adjusted group mean methylation or mean within-pair difference and its SD [using the standard error (SE) of the mean] and test for group differences.

Quantile regression suggested shifts in methylation distributions associated with air pollution exposure that were not captured by corresponding least-square estimates of the difference in (or ratio of) mean methylation associated with exposure.

β-values range from 0 (unmethylated) to 1 (100 % methylated) and were used to identify the mean percentage methylation difference between fusion-positive and fusion-negative PCa.