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For all days combined the mean maximum score was 25.3 points.
Before antibody injection most of the mice had active arthritis (mean maximum score 8.1 ± 2.0).
aShows the mean incidence and the mean maximum score of mice with the respective genotypes on markers D5Mit113 and D5Mit136.
a Values for incidence, onset, mean maximum score and area under the curve (AUC) are the mean phenotype values for the respective congenic mice.
The mean maximum score, representing disease severity, was calculated as the mean of the maximum score of all sick mice in the respective groups.
Items with an AUCROC of 0.65 or less or with a non-significant (P ≥ 0.05) difference between the mean maximum score were excluded.
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The mean maximum scores were 10.1 in case-patients and 3.4 in control-patients.
The maximum Bedside PEWS score increased with increasing proximity to ICU admission from mean maximum scores of 5.3 to 6.0 more than 12 hours before PICU admission to 9.5, 0 to 3 hours before PICU admission (P < 0.0001, Figure 2).
The difference between the mean maximum scores of case and control patients ranged from 5.8 in the core item only score, to 6.9 in the score with all eight items.
Table 3 shows item-level statistics for the 36 items included in the final analysis, with means, maximum scores and difficulty of each item according to scenario.
2 3 Imputation rules, such as using a value from the observed population (mean, median, maximum scores of changes from baseline), can be used to estimate progression in patients with missing radiographic data; however, the impact of these different assumptions on population outcomes has not been published.
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