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Besides, pharmacokinetics study also proved that the mean relative bioavailability (AUC) and mean maximum concentration (Cmax) of pellet-SMEDDS were not significantly different from the original liquid SMEDDS (p > 0.05).
In contrast in only SIV-infected pigs the level of Hp in serum increased significantly only at 1 and 2 dpi and reached considerably lower value (mean maximum concentration 1.8 mg/ml) [ 4].
Table 4: ANOVA results for mean maximum concentration (Cmax) and area under curve (AUC) from the time 0 hours to infinity for Gamma Tocotrienol.
Table 5: ANOVA results for mean maximum concentration (Cmax) and area under curve (AUC) (dose adjusted) from the time 0 hours to infinity for Delta tocotrienol.
The mean maximum concentration reached over 54 μg/ml and was almost 3-fold higher than it was before inoculation.
The geometric mean maximum concentration for the applicators was 64.2 μ g/L and occurred on the day after application.
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This means maximum concentration.
Mean maximum concentrations (Cmax) for quinocetone was found to be (0.56±0.13) μg mL−1 at 2.92 h, after oral administration of quinocetone.
The mean maximum concentrations (Cmax) of M1 and M2 after intravenous administration of MEQ were (5.27±1.59) μg mL−1 at 1.78 h and (1.01±0.29) μg mL−1 at 0.92 h, respectively.
Mean maximum concentrations (Cmax) for 1-desoxy quinocetone after intravenous or oral administration of quinocetone were (0.0095±0.0012) μg mL·1 at 0.083 h and (0.0067±0.0053) μg mL−1 at 3.08 h.
Mean maximum concentrations of the drug in serum and areas under the concentration-time curve from 0 to 24 h were approximately proportional to dose.
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