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Mean match probability was calculated as the sum of the squared genotype frequencies per locus.
Even though the CEPH pedigree sample contains related individuals, the mean match probability is still lower than any non-European population by 2 orders of magnitude.
Additionally, familial relationships do not significantly diminish the (mean match) probability of sharing SNP genotypes in pedigrees, further indicating the uniqueness of the "barcode".
Using estimated genotype frequencies for HapMap samples mean match probability was calculated by population and identically estimated for the in-house genotyped CEPH pedigrees.
Dropping the least informative markers of any same-arm set reduces the panel to 42 SNPs and increased the mean match probability by no more than 3.3 orders of magnitude and no less than 1.7 for each population.
Consistent with the low mean match probability and our observations in pedigrees, the panel is clearly able to deliver a globally unique profile or barcode for tracking samples and enable straightforward quality assurance in human genetics research.
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When examining the Human Genome Diversity Panel HGDPP) data from seven populations the mean match probabilities were between 10−13 and 10−18.
Consistent with the original work on this panel [6], we found mean match probabilities comparable to those previously observed in four populations from the three continental groups most commonly used as subjects in genetic analyses.
drandom match probability.
This occurs with probability πQ, the match probability for Q.
We refer to this probability as multi-locus match probability (MP).
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