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(F ) Mean mEPSC frequency.
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Or do they think the mEPSC frequency decrease and spine number decrease are related to the LTP deficit?
For normalized mEPSC frequency calculation, the mean of the entire control group was considered 100%.
(I ) Quantification of AMPA-type mEPSC mean frequency and (J ) mean amplitude.
In contrast to Nulls, LM22A-4 had no significant effect on Wt eEPSC amplitudes and mean sPSC frequency and amplitude (supplementary material Fig. S1A; RM-ANOVA, n.s).. Analyses of mEPSC frequency and amplitude distribution curves in the presence and absence of LM22A-4 revirtuallyrtually identical distributions in Wt cells (supplementary material Fig. S1B).
Or, do the authors think there was a slight effect of ryanodine in mEPSC frequency that did not reach significance?
GBP also attenuated FL-induced increases in mEPSC frequency at both P7 and 28.
If caffeine application increased mEPSC frequency, and these mEPSCs were larger than the baseline events, this would have resulted in an apparent increase in mEPSC size.
Caffeine increased mEPSC frequency in all seven cells, consistent with previous work [4].
The increase in mEPSC frequency is consistent with a presynaptic mechanism.
These data confirm that caffeine increases mEPSC frequency in neocortical neurons, and demonstrate a reduction in mEPSC amplitude not previously described.
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