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Normal bone marrow (n = 3) incubated with 50 ng/ml DTLIL3 for 24 h showed a mean log kill of 0.3 in the CFC assay.
They showed that the mean log kill value was three (SD ± 0.3) and the mean loss of optical density (OD) was 89% (SD ± 3).
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Abbreviators: N: Hill's slope; ED50: effective dose to reach 50% of Emax; BD: bacteriostatic dose; 1LKD: 1 log kill dose; SEM: standard error of the mean; Bold numbers: not statistically different from zero, invalid parameter.
At 5 mM, there was 3.87 log decreases in the mutant in contrast to 1 log kill in the WT.
In contrast, there are 3.64 and 2.68 log kill in macrophages of WT mice.
The maximum-likelihood estimate of the log kill for the ID regimen is 6.9 logs.
The estimated log kill for intermediate-dose therapy from CALGB #9082 was 6.5 logs, compared with 9 logs or greater for high-dose therapy.
F4 showed moderate activity (mean log GI50 1.05), while F5 showed weak activity (mean log GI50 1.36).
To estimate the log kill of therapy of ID intensity on sensitive tumours in the Peters study, this estimate of 48% was used to derive a family of RFS curves as a function of the log kill.
A similar convention applies to logarithms, where log2x usually means (log x 2, not log log x.
At 25 μM, a 3-log kill was observed.
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