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(G and H ) Mean number of sequences (in Z -score) (G ) and mean location shift (H ) for the sequences detected on the novel trajectories in WT and Tau mice.
The robustness of this sequence detection result is examined in Figure 3 figure supplement 4. (C and D ) Mean number of sequences per lap (C ) and mean location shift (D ) for the detected sequences in WT and Tau mice.
The mean location shift of the detected Tau template sequences was significantly greater than that of WT sequences.
The mean location shift values of both WT and Tau sequences shown here were smaller than those on the familiar track, probably due to the shorter length of the novel track.
The mean Z-scores of WT and Tau template sequences on the novel trajectories were similarly high, but the mean location shift of Tau sequences among laps was greater than that of WT ones.
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In contrast, Figure 3 shows the estimated power curves for another dimension of the SF-36: RP, which can only take one of five discrete values (as shown in Figure 1c), for detecting a simple location shift (mean difference) δ = 5.
Figure 2 shows the estimated power curves for Methods 1, 2 and 3 and the two bootstrap methods (t and MW tests) at the 5% two-sided significance level for detecting a location shift (mean difference) δ = 5 in the SF-36 GH dimension using the data from the general population as our pilot sample, for sample sizes per group varying from 50 to 600.
Using Method 1, assuming a standard deviation σ of 20 and that a location shift or mean difference (μET - μEC) of 5 or more points between the two groups is clinically and practically relevant, gives a standardised effect size, ΔNormal, of 0.25.
The location shifts were computed as such for all combinations of laps and their mean value was determined as the location shift for the template sequence on its trajectory.
If the distribution of the HRQoL outcome is expected to be skewed then the MW test appears to be more powerful at detecting a location shift (difference in means) than the t-test.
The location shift should be of no concern because the duration of the training symbol is just 4 μs, which means that a moving speed of 900 km/h is required to observe a location shift of 1 mm.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com