At 12 months, patients in the insulin cohort also had improvements in mean BP and lipid parameters (see Table 3).
Mean changes in lipid parameters, total cholesterol, low-density lipoprotein cholesterol and triglycerides from baseline to week 48 after initiation of treatment were significantly lower in the rilpivirine group in THRIVE.
18 Patients with abnormal baseline (LDL ≥100 mg, HDL ≤40/50 mg/dL [male/female], or triglyceride ≥150 mg/dL) showed greater improvements in all lipid parameters (LDL, mean: −12.7 [SE =1.61] mg/dL, P<0.0001; HDL: 2.5 [SE =0.34] mg/dL, P<0.0001; triglycerides: −21% [SE =1.9], P<0.0001) in contrast to the moderate improvements in all patients receiving exenatide weekly.
Here, higher mean levels of HDL-C and lower mean levels of the other investigated lipid parameters were registered in the GT/TT genotype carriers than in the GG carriers.
Interestingly mean values of all the tested lipid parameters were seen in normal range in two groups and none of the tested lipid parameters were identified as predicting factors of pathogenesis of two types of GS.
Here, higher mean levels of HDL-C and lower mean levels of the remaining above mentioned lipid parameters were registered in the GT/TT genotype carriers than in GG carriers.
It was observed that neither mean age nor any of the five lipid parameters namely TC, TG, HDL, LDL and VLDL differs significantly among the two sub-groups (p > 0.05).
Estimated marginal means with 95% confidence interval of the lipid parameters in association with genotypes were evaluated utilizing general linear model adjusted for age, gender, BMI, type 2 diabetes, smoking, hypertension, and lipid-lowering therapy.
Whereas several OCT-derived plaque parameters are predictors for ACS, only mean lipid arc, lipid plaque length, presence of macrophages and minimal FCT were independent predictors.
The main findings of this study in patients with type 2 diabetes are: Whereas several OCT-derived plaque parameters are predictors for ACS, only mean lipid arc, lipid plaque length, presence of macrophages and minimal FCT were independent predictors.
