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Aβ1 42 flies with the Atg1+/− genotype have a 10.9% increase (log-rank P<0.0001) in mean lifespan compared with Atg1+/+ genotype (Fig. 8B).
In contrast to Aβ1 42 flies, control flies with the Atg1+/− genotype have a 13.6% decrease (log-rank P<0.0001) in mean lifespan compared with Atg1+/+ genotype (Fig. 8B).
Overexpression of DAGL/ inaE resulted in a 41% increase (P < 0.001) in mean lifespan compared to Gal4 alone and 16% (P < 0.001) compared to UAS alone (Fig. 2A).
Adult fer-15 nematodes exposed to strain 536 have a 50% shorter mean lifespan compared to nematodes exposed to the OP50 strain [ 19].
Mean lifespan in female Snell with a DW/J background is increased by approximately 50% compared to normal controls, while male Snell dwarfs have an approximate 29% increase in mean lifespan compared to their respective sex-specific controls (Flurkey et al., 2002).
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The lifespan of nth-1 was indistinguishable from the wild type, as was recently shown [ 7], whereas the xpa-1 mutant displayed reduced lifespan compared to the wild type (mean survival of 14.5 and 17.3 days, respectively).
Mean lifespans were compared using the log-rank (Mantel-Cox) test, and mortality at more specific time points was compared using Fisher's exact test.
Here we tested different constructs and generated a specific anti FRH-1 antibody, to specifically correlate level of fratxin protein expression, lifespan and other animal metabolic parameters and clearly showed that none of tested constructs actually shortened lifespan compared to control animals (which have a mean lifespan of almost 18 days, Table 1).
GLM univariate procedure revealed higher contribution of Ap to the variance of lifespan compared to season of death.
Consequently, AID−/− mice had a significantly shorter lifespan compared to wild type mice.
PF also dramatically extends adult lifespan compared to YF.
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mean ages compared
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mean diffusivity compared
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