It means early intervention where parents are struggling to parent, excellent early-years education, not plunging families into financial chaos by cutting in-work benefits, turning failing state schools (disproportionately likely to be found in poorer neighbourhoods) around, and somehow nurturing the creation of more decent well-paid jobs.
Using the same methods as for the actual EQ-5D data (see above), these predicted EQ-5D scores were then used to estimate the QALY gain for each individual who had complete study data, and the mean QALY gain for each intervention, where these calculations were performed for both our preferred model, and our preferred Grootendorst et al. model.
Researchers are increasingly using these resources 1 which provide a means for researching questions in primary care that cannot feasibly be addressed by other means, including unintended consequences of drug interventions, where ethical considerations, the required numbers of patients, or length of follow-up can make a randomised controlled trials impractical.
Our population is different from those in other studies of similar interventions where participants were more functionally able at baseline: mean Barthel index score of 18.7 16 and 19.0.
In this paper, we emphasise the need for a holistic approach to computer-assisted interventions where clinical, scientific, engineering and regulatory expertise are combined as a means of moving towards clinical impact.
By observational studies we mean studies where the intervention has not been assigned as a part of the research project, in particular not assigned by some random mechanism.
The treatment is an intervention for promoting physical activity and the outcome data are standardised mean differences, where a positive mean difference indicates that the intervention has a positive effect on promoting physical activity.
The number of interventions and the interval between interventions varied considerably between patients, ranging from 1 to 40 interventions over the follow-up period (mean 7.8 interventions, median 5 interventions, SD 8.3 interventions).
Mean adherence (where stated) was 75%.
In extremis, it might mean military intervention.
