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Exact(7)
Mean injected dose was: 200 MBq.
Mean injected dose and specific activity were not significantly different between groups at any time point (t test, p >.05; Table 1).
Patients who had fasted for 6 h previous to the examination were injected with 18F-FDG after 15-min of rest in a warm room (mean injected dose ±SD = 3.89 ± 0.44 MBq/Kg).
MRI and PET images using F-FDG (mean injected dose of 185 MBq) were acquired and analyzed using FreeSurfer to define regions of interest in the hippocampus, amygdala, precuneus, and anterior and posterior cingulate cortex.
A mean injected dose was calculated from the injection standards, and the injected activity of 125I-Fab for each mouse was calculated by subtracting the residual activity in the syringe from the mean injected dose.
The mean injected dose was 200 MBq.
Similar(53)
Equation (3) [ 10, 11] was used to calculate drug concentration in each organ, in which ID meant injected dose and pure M was pure weight of each organ(s) as follows: (3) % ID gr Organ = eac h count tota l count × 100 pure M.
Values are mean percentages injected dose per gram tissue (n = 4. Error bars SD).
Results of the radiolabelled antibody distribution over time were calculated as the mean percentage injected dose per gramme (%ID/g ± SD) for each mutant and parental hu3S193 per time point.
Mean percent injected dose per cell was determined by dividing the huA33 uptake (%ID/g), calculated using the autoradiographic images, by the total number of cells in each field, determined by manual cell counting in digitized high-power H&E images.
Statistical analysis of the %ID/g variation in the PET scans and biodistributions were performed with GraphPad Prism 5.0 (San Diego, USA) as a parametric two-way ANOVA test with Bonferroni post-test, while the mean longitudinal percentage injected dose per gram (%ID/g) and the post-LPS treatment weight variation were analysed with a Student's t test.
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