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At the endpoint of the symptom-limited bicycle ergometer exercise, 740 MBq of 99mTc-N-DBODC5 (mean injected activity, 740.8 ± 11.1 MBq) was injected; exercise was continued for a further 2 min.
A mean injected activity of 207.8 ± 9 MBq was injected in order to exclude potential confounding dead-time effects in the PET detectors which has been shown to occur in clinical situations (O'Doherty et al., 2014; Renaud et al., 2016).
The mean injected activity was 181 ± 14 MBq.
The mean injected activity was corrected for the mean residual activity after administration.
The effective dose was 6.1 (SD 0.9) mSv for a mean injected activity of 690 (SD 35) MBq.
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F ab' 2 localised more rapidly than intact antibody in tumour, giving a mean percentage injected activity per kg at 4.25 h after injection of 8.2% for F ab' 2 compared with 4.4% for intact antibody (P < 0.05).
An example of the correlation of the CLI signal with the PET signal (x-axis, expressed in mean percent injected activity per gram) is shown in Fig. 11 (top).
Mean (SD) injected activity was 4 (0.2) MBq per kg of body weight.
Mean ± SD injected activity was 4.1 ± 0.5 MBq per kg of body weight.
Normalising C mean corr to the injected activity and the patient weight leads to the PVE corrected SUVmean. Figure 1 Illustration of the partial volume effect.
In contrast, image-derived IFs were significantly underestimated (mean IF corrected for injected activity shown in Figure 2) compared to either manual sampled or probe-derived IFs.
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