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Mice bearing WM266.4 tumours (mean initial volume 559±51 mm, n=9) received 75 mg kg−1 selumetinib, while those with Colo205 tumours (mean initial volume 484±63 mm, n=6) received 50 mg kg−1 selumetinib.
Gobin et al. [ 14] reported their experience with NBCA embolization followed by LINAC (25 Gy) in large AVM (mean initial volume 22 cm).
Mathis et al. [ 12] embolized 24 AVMs with a mean initial volume of 37 cm prior to GKR and noted a 50% obliteration rate with only 4% morbidity.
Belimumab was distributed to tissues with a mean steady-state volume of distribution ranging from 69 to 112 ml/kg, representing approximately twice the mean initial volume of distribution, which ranged from 40 to 57 ml/kg.
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Most MIN lesions developed in the mid (10/21) or lower (9/21) gland regions, at a mean (± standard deviation) age of 12.7 ± 2.6 weeks and an average initial volume of 0.34 ± 0.22 mm.
The mean initial cyst volume was 1,052 ml.
The mean observation period was 26.2 months (6.5 74.8) and the mean initial tumor volume was 6.2 ± 6.5 cm (0.14 30.5).
The vehicle-treated mice (mean initial tumour volumes of 592±46 mm (n=6) and 512±40 mm (n=5) for WM266.4 and Colo205, respectively) received water only.
The mean initial planning target volume was 735.0 cm3 (SD = 266.7 cm); the mean boost volume was 399.7 cm3 (SD = 239.2 cm).
The mean initial intracranial haemorrhage volume was 16.8 mL (SD 23.8) in the tranexamic acid group and 19.8 mL (28.3) in the placebo group.
In the KB tumor model, the mean tumor volumes at different days were calibrated by normalizing the initial volume (at day 0) to 1.
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