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Compared with leaflet provision, dietary intervention plus quadriceps strengthening exercises was both more costly (mean incremental cost £646.71, 95% confidence interval £578.15 to £709.62) and more effective (mean incremental effect 0.062, −0.035 to 0.167), with an estimated incremental cost per QALY gain (incremental cost effectiveness ratio) of £10 469.44 (£3738.28 to dominates) (table 1).
This is not necessary equal or close to the ratio of the mean incremental cost and mean incremental effect, which is the deterministic version of the ICER.
A cost-effectiveness analysis will be performed, weighing incremental costs against the mean incremental effect in terms of quality of life based.
The mean incremental costs were weighted against the mean incremental effect in terms of QALY.
In the analyses from both perspectives the mean incremental health care costs were weighted against the mean incremental effect in terms of quality adjusted life years (QALY).
20 For each data set simulated, the incremental net benefit (INB) was computed using the relationship: INB=λ*ΔE ΔC, where λ is the CE threshold, ΔE, the mean incremental effect and ΔC the mean incremental cost.
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The mean incremental costs were weighted against the mean incremental effects in terms of QALY.
Table 4 shows mean incremental QALYs and mean incremental costs compared with treatment as usual.
For calculation of the ICER, mean incremental policy costs will be divided by the mean incremental QALYs.
We denote the population mean incremental net benefit (mean INB) by ΔB K).
1000 Monte Carlo simulations resulted in a mean incremental cost for Argus II of 42,018 Euros and mean incremental QALYs of 2.90.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com