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By its definition, it is not a point to point correlation as several in vivo curves can produce a similar MRT value or mean in vitro dissolution curve.
Geometric mean in vitro IC50s of desbutyl-lumefantrine for laboratory-adapted Plasmodium falciparum parasites were 9.0 nM for chloroquine-sensitive (3D7) and 9.5 nM for chloroquine-resistant (W2mef) cultures (14).
Clinical isolates expressing the H275Y mutation show high-level oseltamivir resistance (mean in vitro 50% inhibitory concentration [IC50] ± standard deviation [SD], 679.5 ± 44.5 nM) and intermediate peramivir resistance (mean IC50 ± SD, 36.5 ± 7.8 nM) without a change in zanamivir susceptibility [ 32]; the clinical significance of this finding, however, is not clear.
The mean in vitro dry matter (DM) digestibility was 603.8 g/kg DM (± 37.1 s.d).
The mean in vitro endotoxin activity of Plow and wP were assessed at 1.54*10 and 0.53*10 IU endotoxin/mg protein, respectively.
The mean in vitro dissolution or release time is compared to either the mean residence time or the in vivo mean dissolution time.
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Personhood measures also raise questions about what they would mean for in vitro fertilization, which often involves creating more than one embryo in an effort to help a woman conceive — the American Society for Reproductive Medicine has been against personhood initiatives — and the "morning-after pill," which is essentially a high dose of birth control pills that delays ovulation.
The huge variability of flavonoids in the natural environment [ 35- 37], coupled with the wide range of factors that may influence their production and accumulation means an in vitro experiment would be entirely disconnected from nature and is unrealistic.
This means that in vitro studies of discrete functions, such as the in vitro effects of IFNλ on an isolated cell type, may tell us little about the in vivo effects in a particular disease setting where a complex interplay of cell types and inflammatory stimuli is at work.
Among different delivery means, in vitro transcribed Cas9 mRNA/gRNA, purified Cas9 protein, and adeno-associated virus (AAV) driven seem promising toward clinical applications (Kouranova et al., 2016; Lin et al., 2014; Yin et al., 2016).
Twenty nine (3.3%) of the IMA cohort mothers had conceived by assisted means (in vitro fertilisation, intracytoplasmic sperm injection, etc).
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