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Doctors and nurses are keen to draw a distinction between palliative medicine – which is sometimes taken to mean high doses of morphine at the very end of life – and palliative care, with the psychological support it offers to the dying and their relatives, as well as pain relief.
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In a study of 296 patients with poorly controlled glycemia (mean A1C8.4%%) requiring high doses of basal insulin (≥30 units/day), either 50 mg vildagliptin twice daily or a placebo was added for a 24-week period (15).
Does it mean that higher dose or frequency will bring better effect?
The problem is that we have no correct understanding of what 'dose' means and higher doses implicitly mean more complications and/or comorbidities.
For these patients, the mean (very high) dose of fluvastatin was 56 mg.
In many toxicological assays, interactions between primary and secondary effects may cause a downturn in mean responses at high doses.
At extremely high doses, mean arterial pressure was observed to be significantly reduced, which may reflect an additional vasodilatory or negative inotropic action of HCQ.
However, this does not necessarily mean that a high dose of radiation has to be delivered to the patient, as special detector design (e.g. flat panel CT) and dose reduction techniques (e.g. iterative reconstruction algorithms) are nowadays available.
Graft-versus-host disease (GVHD) was induced in Hooded (Rt1c) strain rats by means of high dose total body irradiation (TBI) and subsequent reconstitution with allogeneic bone marrow and spleen cells from WAG (Rt1u) strain donors.
I think this kind of thing will turn up all over once people start looking". In the paper, Ames and Elson-Schwab estimate that up to one-third of all mutations in a gene may affect binding to a vitamin-derived coenzyme, which means that high-dose vitamin therapy might reverse the effects of these mutations.
This means a higher dose must be administered and maintained.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com