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Dose constraints for normal tissues were defined as: spinal cord, <48 Gy; mean heart dose, <40 Gy; and lung, V10 < 50%, V15 < 40%, V20 < 25%.
The current average mean heart dose is likely to be around 2 7 Gy for left-sided (Taylor et al, 2008; Jagsi et al, 2010; Schubert et al, 2011) and around 1.5 Gy for right-sided breast cancer radiotherapy (Taylor et al, 2008).
Scandinavian data detected the rate of major coronary events was proportional to mean heart dose [ 42]; with improved homogeneity of radiation dosing using 3D and 4D computed tomography planning and intensity-modulated radiation therapy, a decrease in late toxicity is expected [ 43– 43].
Mean heart dose averaged 3.0 Gy ± 0.8 Gy.
We conducted a prospective trial to determine if RT with the Active Breathing Coordinator (ABC) can reduce the mean heart dose (MHD) by ≥20% and dose to the lung.Patients with stages 0-III left breast cancer (LBC) were enrolled and underwent simulation with both free breathing (FB) and ABC for comparison of dosimetry.
The mean heart dose delivered using STgF was lower than HTgF.
Similar(42)
However, we noted lower mean heart doses with our tangential IMRT (2.7 Gy with free-breathing and 1.5 Gy with breath-hold).
Peak heart rate and mean heart rate showed similar relationships.
Red means heart.
Peak hsTnT and NTproBNP as well as mean heart rate and dose of given norepinephrine had a p value <0.10 and were included in the multivariable analysis.
Secondary predictors, with a p value <0.10, were high cerebral blood flow velocity, mean heart rate and dose of given norepinephrine.
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CEO of Professional Science Editing for Scientists @ prosciediting.com