In Shekalaghe 2007, although there was also no reduction in mean haemoglobin by group (Analysis 2.5), there was a significantly greater change (decrease) in haemoglobin status in the PQ group on day 8; haemoglobin decreased by 5% in the PQ group compared to 1% in the non-PQ group (Analysis 2.6).
External validity was assessed by means of known-groups analysis.
Had this family undergone post-mortem microarray analysis as a part of a larger sample of subjects, EVA would have detected the MAOA decrease in expression whereas microarray analysis using mean group effects would not have.
The data of Greer et al. (2002) point toward a more sensitive subgroup, which in this case represents more than half of the test group but is not evident in the group mean analysis due to the variable nature of the response.
As planned a priori, the possible differential treatment effect for patients without HIV viral suppression was explored by means of a sub-group analysis, examining the differences in HAI titre doubling for the 72 patients with non-suppressed HIV viral load in comparison to the 226 with viral load suppression (Figure 4).
The relative rarity of stillbirth in this population means estimates in sub-group analysis have in some cases been calculated from a small number of events, resulting in wide confidence intervals.
Preliminary results showed that, by week 60, PASI-75 responses were observed in 49% of the ITT population (n=339) and in 57% of patients (n=290, last observation carried forward) who were analyzed by means of a maintenance group analysis, which included only patients eligible to receive continued efalizumab.
The results of comparative single-group mean analysis of the test scores suggest that the learning modules were potential in assisting students to progress through the respective van Hiele's levels of geometry thinking, with all of them demonstrated progression of at least within level.
The genetic structures of sampled populations and individuals were estimated by unweighted pair group mean analysis (UPGMA) using TEPGA, version 1.3 [ 58], with 5,000 of permutations.
Consistent with the original report and the group mean analysis, substantially more patients receiving etoricoxib or naproxen achieved various thresholds of response for both BASDAI and spine pain than did patients receiving placebo, where active treatments were significantly more effective than placebo for both measures (p < 0.001) [ 12].
