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Mean group activation maps were created for typical and atypical lateralization groups using a random-effects model in SPM8.
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Group activation is shown in Fig. 1b.
Group mean activation maps for the atypical lateralization group showed activation in homologous regions of the right hemisphere compared to those in the typical lateralization group (Fig. 2A).
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Because the patients showed a range of performance and damage, standard functional MRI contrasts looking at group mean activation are likely to be insensitive to highly variable activity in key areas.
Since the patients showed a range of performance and damage, this variability is more likely to be informative for establishing the relationship between damage and performance than standard functional MRI contrasts on group mean activation.
Correlations between baseline GABA NAA ratio and BOLD signal change in response to the motor performance contrast were masked post hoc by the group mean activation in response to the motor performance contrast.
Correlations between GABA NAA change after tDCS and BOLD signal change in response to the learning regressor were masked post hoc by the group mean activation in response to the learning contrast.
We performed conjunction analyses (conjunction null) to determine common areas of mean brain activation in each group and among the questionnaire regressors in patients only.
The Connec patients with intact LIFG (n = 5) showed greater mean LIFG activation than either the normal group or the LIFG-intact Connec patients (n = 7) (P = 0.007 and P = 0.022, respectively); LIFG activation in the latter two groups did not differ significantly (P = 0.53) (Fig. 4).
Differences in mean activation between groups were assessed for each task contrast separately using the two-sample t-test.
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