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TIV, inactivated trivalent influenza vaccine; Seropositive, titer ≥1 10; GMT, geometric mean titer; MGI, mean geometric increase defined as the geometric mean of the ratio between pre-vaccination and post-vaccination reciprocal titers.
QIV, inactivated quadrivalent influenza vaccine; Seropositive, titer ≥1 10; GMT, geometric mean titer; MGI, mean geometric increase defined as the geometric mean of the ratio between pre-vaccination and post-vaccination reciprocal titers.
The two doses of nasal vaccine induced serum HI titers, demonstrated by a > 4-fold mean geometric increase, a > 40% conversion rate or significant increase in titer, and a > 70% protection rate in subjects aged 18 60 y (Table 2 and Fig. 1).
They showed a 1.63-fold and a 2.12 mean geometric increase, respectively.
The mean geometric increase in the cross-reactive HI and NT titers were very similar and showed a 1.44-fold and a 1.46-fold, respectively.
In addition, the nasal vaccine induced HA-specific IgA and IgG antibodies in nasal mucus, demonstrated by a 3.88-fold and 1.37-fold mean geometric increase, respectively (Table 5).
Similar(47)
Geometric mean Cmax increased in a less than dose-proportional manner in the dose range of 75 mg BID to 300 mg BID.
Geometric mean BLLs increased by tertiles of both BAP and NTx (p-value for trend < 0.001) in the overall study population (Table 1).
Geometric mean Cmax increased two-fold between the 300 and 600 mg BID dose level and subsequently increased in a less than dose-proportional manner up to 1500 mg BID.
Geometric mean plasma EPO increased with age and TfR increased to 3 months then leveled off (see Table 2).
"They need a geometric increase".
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