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The mean gametocyte density was 22.2/µL (SE 3.1, range 4 908).
The mean gametocyte density (excluding zeros) was 18.4/µL (SE 2.4, range 4 208).
Children carrying anti-GSA plasma antibodies at the day blood was donated for DMFA were found to have a lower mean gametocyte density at day 28, but this was affected by the treatment received.
The area under the curve was significantly lower for SP+AS+PQ treated children (t-test t = 3.28, p <0.001), as were the number of sampling times when gametocytes were detected (GEE: OR = 0.27 (95% CI = 0.18 0.40), p<0.001) and the geometric mean gametocyte density in gametocyte positive samples (GEE: β = −0.40 (95% CI = −0.74−−0.07), p = 0.02).
We estimated log(10 AUC values using geometric mean gametocyte density.
The geometric mean gametocyte density was 71.7 gametocytes/μL (95% CI 53.8 95.6).
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It is important to use individual host estimates of gametocyte density instead of mean estimates as the high degree of gametocyte overdispersion among hosts may accentuate the non-linear relationship between gametocyte density and mosquito infection.
In a site in Burkina Faso, children harbour more gametocytes than adults though the non-linear relationship between gametocyte density and mosquito infection means that (per person) they only contribute slightly more to transmission.
The efficiency with which P. falciparum gametocytes can infect mosquitoes means that transmission-reducing interventions, which reduce gametocyte density, will need to be highly effective in order to reduce human mosquito transmission.
Using PCR-detected gametocyte density estimates, Shekalaghe 2007 provided geometric mean and interquartile range (IQR) values on days 1, 4, 8, 15, 29 and 43.
However, the relationship between gametocyte density and mosquito infection established here means that adults are only 37% less likely to infect mosquitoes (infecting on average 3.5% of them, Figure 2B).
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