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At the time of writing, 82 participants had attained a mean final height of 151.8 (SD 6.4) cm, and 10 others continued growing.
According to Davenport [ 3], the mean final height in TS girls is 20 cm below the mean of the normal girls.
Target height can also be expressed as SDS (Z-score), by taking the difference between TH and the mean final height of a young adult of the same sex, and then divide by the SD at that age.
Assuming a standard deviation of 5 cm, we needed 50 girls in each group to detect a difference between groups in mean final height of 2.8 cm with 80% power at 5% significance a total of 100 patients.
The mean effect on final height of oxandrolone, late induction of puberty, or both compared with placebo and early induction was +7.1 cm (that is, the mean final height in the combined oxandrolone/early, oxandrolone/late, and placebo/late groups compared with the placebo/early group), which is appreciably larger than the effects for either randomisation alone (table 3, combination).
Treatment has been well tolerated, such that dropout rates were low (14/106) and the mean final height for the group to date (151.8 cm) is well above the target of 150 cm for girls with Turner's syndrome treated with growth hormone.
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By twice randomised group, the mean final heights were placebo/early induction 147.0 cm, placebo/late induction 153.1 cm, oxandrolone/early induction 154.4 cm, and oxandrolone/late induction 155.1 cm (table 1).
The mean final VA was 20/125.
Short stature in Turner's syndrome relates to impairment of each phase of the infancy-childhood-puberty model of growth, 1 and it results in a mean untreated final height approximately 21 cm below that of the unaffected female population. 2 The mainstay of treatment for short stature is recombinant growth hormone, available since 1985 and licensed for use in Turner's syndrome.
Usually it means final.
Final, however, means final.
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