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The regulatory program uses the expression levels of the set of regulators to predict the condition-dependent mean expression of the co-expressed genes.
In healthy mice synovial CD3 T cells expressed TNF-αR1 (mean expression of 1,006 ± 345), while CIOA mice showed low surface expression of the receptor (mean expression of 95 ± 12).
Normalization factors were estimated as the geometric mean expression of 5 control genes using geNORM [35].
SAM also reported the fold change in the mean expression of the target genes in the 5-aza/TSA treatment group versus the control group (Figure 1B).
Before clustering, protein expression values were normalized on a gene-by-gene basis and the mean expression of each sample was centered to the same value.
Xenografts revealed a mean expression of 3.9 ± 4.9%.
The mean expression of RUNX3 is significantly higher than the mean expression of RUNX1 (t-test, df = 13, P < 0.0002).
The surface expression of IFN-γR1 increased in CIOA mice (mean expression of 1,496 ± 213) which was down-regulated by glucosamine (mean expression of 595 ± 87).
The mean expression of the genes in mixture component one was between a half and a third of the mean expression of the genes in mixture component two.
Gene expression fold changes were calculated by dividing the mean expression of one group (e.g. cancer samples) by the mean expression of the other group (e.g. nonmalignant samples).
The relative mean expression of mipep in grade II tumors was 0.015 (±0.0038).
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