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Our results showed that the negative correlation between transcriptional noise and mean expression is not determined by distal CRMs but is solely promoter derived for vertebrate Msx1.
Evolution of CUP1 toward higher noise in its expression is conceivable: High mean expression is both advantageous in high copper concentrations and disadvantageous for fermentation.
Although it is the simplest and the most widely used practice that regards a pathway being up-regulated if the mean expression is positive and down-regulated if negative, such a rationale lacks solid biological support.
The condition mean expression is normally distributed μ m (c ) ∼ Norm (μ m (0), 1/(λ m (c )λ0)) with mean μ m (0), which is empirically calculated from multiple samples and scaled precision λ m (c )λ0.
Discussion, paragraph 4: Since the result of " most asymmetric duplications tend to be observed in gene families with the highest mean expression" is inconsistent with the previous study, then why both observations are consistent with the prediction of "widespread neofunctionalization occurring more frequently in household genes with high and ubiquitous expression"?
A higher expression for one version was associated with lower noise only in 2/6 cases among these promoter pairs whereas higher mean expression is generally accompanied by decreased expression variability (Bar-Even et al. 2006; Newman et al. 2006; Hornung et al. 2012; Carey et al. 2013).
Similar(53)
Furthermore, the expression level was normalized by Z-transformation (the mean expression was set to 0 and standard deviation to 1 for each gene in each dataset).
First, the mean expression level for each miRNA in all experiments was calculated, and then a 2nd degree polynomial function F for fitting each experiment signals to the calculated mean expression was found.
Probe sets with high (P>0.10) "detection P" values (Affymetrix algorithm) for more than half of the arrays from the group with higher mean expression were excluded from further analysis, which reduces the number of false positives [53], [55].
For galectin-3, mean expression was -0.3 (SD 0.88) and -0.9 (SD 0.53) respectively.
If two probes met these criteria for one gene, the probe with the highest mean expression was chosen.
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