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When we used the UCED and exponential growth models, we found that the mean evolutionary substitution rate of the PPRV complete genome was estimated to be 9.09 × 10−4 (95% HPD 2.13 × 10−4 1.64 ×10−4 1.64
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First, the analysis was repeated without data partitioning, so that the protein-coding genes and the rRNA genes shared the same substitution model and mean evolutionary rate.
Bayesian MCMC inference resulted in an estimate of the mean evolutionary rate across Fucaceae of 0.0016 substitutions per thousand years (95% confidence interval 0.0008 to 0.0025).
Note: Ka corresponds to the mean evolutionary rate measured as the number of nonsynonymous substitutions per site.
The mean evolutionary rate of the R5 strains was 1.17×10−2 nucleotide substitutions per site per year (0.1 2.2×10−2 lower and higher 95% highest posterior density, HPD), while the rate for X4 strains was 1.6×10−2 nucleotide substitutions per site per year (0.7 2.6×10−2 lower and higher 95% HPD).
Using the sequences available at the moment and Yule process speciation under a relaxed clock model with an uncorrelated lognormal distribution, the mean evolutionary rate of betaCoVs was estimated at 2.37×10−4 nucleotide substitutions per site per year for the RdRp gene.
The geometric mean evolutionary rate in HIV-1C gag was estimated at 1.23E-05 (95% CI 8.07E-06 – 1.64E-05) substitutions per site per day.
We applied a Bayesian relaxed molecular clock method to the phylogeny and estimated the mean evolutionary rate of the full-length genome of A(H1N1 pdm to be 4.0×10−3 substitutions per site per year (95% probability density ranged 3.6×10−3 to 4.4×10−3: Table 1).
The geometric mean evolutionary rate in HIV-1C env gp120 was estimated at 3.71E-05 (95% CI 1.97E-05 – 5.45E-05) substitutions per site per day.
Mean evolutionary rates (averaged over branches weighted by their lengths) were measured as the number of nucleotide substitution per site per year (s/s/y).
The posterior distribution of the substitution rate obtained from the heterochronous sequences was subsequently incorporated as a prior distribution for the mean evolutionary rate of the influenza A virus genome, thereby adding a timescale to the phylogenetic histories of the given viruses and enabling the times of the most recent common ancestors (tMRCA) to be estimated [24].
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