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DMSO 15% increased mean episode duration of light slow wave sleep (SWS), decreasing mean episode duration of deep SWS and of quiet wake (QW).
Total time spent awake was increased and mean episode duration of wakefulness was prolonged.
DMSO 20% increased light SWS enhancing number of episodes, while decreased deep SWS mean episode duration.
The results demonstrated that SY3 at doses of 20, 40 and 80 mg/kg behaved remarkable action on sleep architecture of rats, which contain the increase of total sleeping time, the rate of deep slow wave sleep (SWS) and mean episode duration of deep SWS, and the decrease of the latency of deep SWS.
However, transgenic animals overexpressing GSK-3β showed alteration in sleep continuity characterized by an increases in number of non rapid eye movement (NREM) sleep episodes (GSK-3β, 227.2 ± 1.7 vs. WT, 172.6 ± 1.4, p < 0.05) and decreases in mean episode duration (GSK-3β, 3.0 ± 0.1 vs. WT, 4.4 ± 0.2, p < 0.05).
The mean episode duration was 80.74 days.
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Model 3 builds from the previous ones by randomly assigning diathesis values to each agent, simulating the experience of a series of agents (the number of which can be changed) and calculating output parameters: the incidence proportion (over the specified interval), the mean first episode duration and the mean episode count over the specified simulation interval.
Middle and bottom plots: show 3-day means of total sleep, mean sleep episode duration and number of sleep episodes quantified in 12-hr day/night bins.
The corresponding unconditional difference-in-differences estimates for PPS and PPP recipients are a reduction of 15% in mean PPS episode duration (see Table 3) and a reduction of 49% in mean PPP episode duration (see Table 4).
Sleep/activity parameters (total sleep, mean sleep episode duration, maximum sleep episode duration, number of sleep episodes, and activity while awake) were analyzed for each 12-hr period of light or dark conditions and averaged across 3 days.
Knockdown of Rdl results in less total sleep loss since an increase in the total number of nighttime sleep episodes partially compensates for the decrease in mean sleep episode duration.
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