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In the Japanese study which used the turbidimetric limulus assay, mean endotoxin levels decreased significantly from 8.84 to 2.11 pg/ml [ 37] after PMX-F, whereas in the European RCT in which endotoxin was measured with the modified LAL assay, endotoxin levels did not change significantly (median, 28 EU pre-PMX-F to 38.5 EU 24 hours post-PMX) [ 28].
Mean endotoxin levels varied significantly from room to room.
Mean endotoxin levels were significantly different between non-septic and septic patients.
Bischof et al. (2002) found mean endotoxin levels of 33.0 EU/mg, also considerably less than our value of 63.9 EU/mg for family room floors.
The mean endotoxin levels (of all sampling occasions) were 28 pg ml-1 (range 14 to 52 pg ml-1) in the control group and 49 pg ml-1 (range 20 to 123 pg ml-1) in the pyometra group.
However, samples taken during surgery (ET 3) or skin suturing (ET 4) showed a significant difference in mean endotoxin levels between the two patient groups (unpaired t-test, P < 0.05).
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More specific comparative analysis of NOC subjects versus subjects with type 2 diabetes at 4-h postprandial identified that the latter had a mean endotoxin level 125.4% higher than that of NOC subjects.
Using the EAA method, patients who were hypotensive on admission had a mean endotoxin level of 440 ± 350 pg/ml, versus 320 ± 330 pg/ml for normotensive patients; however, the difference was not statistically significant (P = 0.18).
We confirmed that LPS levels were higher in plasma from HIV-1 infected subjects compared with HIV-1 uninfected subjects, which was true regardless of whether they were receiving ART (Figure 1A, Mean plasma endotoxin levels for HIV-negative = 0.0119±0.0196 EU/ml, HIV-positive untreated = 0.0188±0.0199 EU/ml, P = 0.022, and HIV-positive on ART = 0.0249±0.0210 EU/ml, P = 0.009)).
By way of illustration, the mean of the endotoxin levels that have been measured in representative cotton factories was 366 EU/m (range, 44 1,871 EU/m) (Astrakianakis et al. 2006a).
Another household factor relating to endotoxin was living in poverty, for which mean bedroom floor and bedding endotoxin levels were 56% (p = 0.003) and 58% (p = 0.021) higher than in nonimpoverished households, respectively.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com