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Drug mean dosage and therapeutic standards for non-pharmacological treatments were considered and summarized, even if not statistically analyzed.
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First patients had a dobutamine infusion (t1) to reach PPC > 70 mmHg (mean dosage 6.7 μg/kg/min), and then, after central hemodynamic and CBF measurements, dobutamine was changed with norepinephrine (0.12 μg/kg/min) (t2), trying to reach the same PPC achieved with dobutamine.
Medicines usage was estimated based on mean dosage when used and average usage within the three budgetary periods (discharge to 3, 3 6 and 6 12 months, respectively).
Mean HOMA-B was significantly higher (84 versus 36; P=0.03) and mean dosage of insulin significantly lower (41.5 versus 69.5 units; P=0.004) in SU responders than in SU non-responders.
In 38 pairs, patients were treated with norepinephrine (mean dosage of 0.72 μg/kg/min), and 63 were under dobutamine infusion (mean dosage of 9.4 μg/kg/min).
We also calculated the mean serum ferritin level and the mean dosage for the three groups.
Table 5 displays the different beta-blocker agents and the mean dosage administered during hospitalization.
Corticosteroids were used in 61%, and the mean dosage of prednisolone (PSL) was 6.2 mg/day.
The mean number of cycles administered was 2.5 and the mean dosage received was 890 mg m2 per injection.
A large part of the elderly group (>60 years) received concomitant antiepileptic treatment, and the mean dosage of ZNS was 475 mg/day.
In another study conducted in 46 ICU patients aged 62.8 ± 15.4 years [ 19], the mean duration of remifentanil infusion was 9.8 hours and the mean dosage was 0.14 ± 0.08 μg/kg per minute.
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