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The mean dissolution times were found to correlate with the average coating thickness measured over all surfaces.
In line with these results, a further study has now implied that in vitro-based mean dissolution times may be an indicator for the in vivo lung absorption rates of slowly-dissolving, lipophilic corticosteroids (e.g., FP, ciclesonide and budesonide) (Rohrschneider et al. 2015).
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Mean dissolution time.
Theophylline mean dissolution time from these pellets was about two to four times greater.
The evaluated responses were mean dissolution time (MDT), crushing strength and elastic modulus of pellets.
Tensile strength and mean dissolution time described minitablets well, unlike compaction force.
The mean dissolution time (MDT) of zidovudine from the SMMs was 5.974 h.
The mean dissolution time was used as a model-independent measure of the overall release rate.
Table 4 Impact of solubility on mean dissolution time of inhaled corticosteroids Drug CS (μg/ml) Do Mean Dissolution Time (hr) Fluticasone propionate 0.14 27 >8 Beclomethasone dipropionate 0.13 15 >5 Budesonide 16 0.375 ~0.1 Flunisolide 140 0.01400.03.
The evaluated responses were crushing strength or yield point, elastic modulus and mean dissolution time (MDT) of pellets.
Inhaled corticosteroids with dose numbers greater than 10 have a mean dissolution time greater than those with dissolution numbers less than 1.
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