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Mean dissolution profiles were compared via calculation of the similarity factor.
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The model-independent parameters such as mean dissolution time (MDT) and dissolution efficiency (DE), calculated on the basis of ibuprofen dissolution profiles in HCl 0.1 mol/L, show that formulation S4 has the shortest MDT such as 7 min and the highest DE of 37% (Table III).
Basically, the mean predicted Cmax and AUC from the respective in vitro dissolution profiles should differ from each other by more than 20%.
The dissolution profiles of each formulation were compared to those of Tegretol® CR tablets and the mean dissolution time (MDT), dissolution efficiency (DE%), and similarity factor (f2 factor) were calculated.
Mean dissolution time.
Those showing dissolution profiles matching at least one of the two sets of control dissolution profiles were defined as "formulations showing similar dissolutions".
Dissolution profiles and their associated dissolution rates were measured using vertical scanning interferometry (VSI).
Dissolution profiles of the tablets were assessed using USP Method II.
Dissolution profiles were determined using the USP paddle method.
Dissolution profiles over 12 h were performed at 0, 5 and 40% ethanol media at multiple time points (26 per profile).
Solubility, dissolution profiles and initial dissolution rate from celecoxib 200 mg capsules were measured in biorelevant and compendial media.
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