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This number is smaller than the 1000 randomly selected reference panels used to calculate the baseline mean discordance rate in the initial analysis, owing to runtime considerations that arise when performing a large number of imputations using the random panels.
Box plots of the results are shown in Figure 6, and mean discordance rates of the various panel types over all sites and over the low-frequency variants are shown in Table 3 and Table 4, respectively.
Results: The mean discordance for 346 twins was 11.4% ± 10.5%.
Duplicates from the Estonian sample were used to assess genotyping reproducibility, i.e. every 40th individual was duplicated and the mean discordance per SNP between pairs of individuals was found to be less than 1 in 5000 (0.0002%).
For a baseline, we also calculated the mean discordance rate over the 1000 randomly selected reference panels.
The baseline for comparison here is the mean discordance rate over the 50 randomly selected reference panels.
Similar(38)
Discordance means that only one mote recorded another mote's signal, but not vice versa.
In 4188 participants (3848 female, mean age 53.4 ± 11.8 years), major discordance, minor discordance, and concordance of T-scores were seen in 2.7%, 38.9% and 58.3%, respectively.
The mean level of discordance (excluding discordance due to genotyping failure of one of the samples) for these SNPs was 5.3% (range 0.40% to 12.96%).
I don't mean to glamorize this grisly act, but rather to talk about the discordance between modern Arab societies and a relentless popular narrative.
Thirdly, discordance at the level of statistical significance does not necessarily mean that results for different outcomes differ beyond chance.
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