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The mean Disability Index for those with MSC was mild to moderate and moderate to severe in those over 55 years.
Gender difference was not obvious from 1997 to 2001, but in 2002 women showed a higher mean disability index score than men (male 0.22, female 0.30, T test, P < 0.05).
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The mean pain disability index was 36/60 (Table 3).
The mean Oswestry disability index improved from 46.5 preoperatively to 18.7 at the last visit in the autogenous bone group with change rate of 57.9%, and in the PMMA group the mean Oswestry disability index improved from 49.8 preoperatively to 17.9 at the last visit with change rate of 62.7%.
Statistical analyses were performed with SPSS 18.0 and Software R. 23 The minimal clinically important difference for change in the mean Oswestry disability index score is considered to be in the range of 8-10 points.
The trial was designed to have 80% power to detect a significant difference of at least 10 points in change in the mean Oswestry disability index score between the intervention groups at two year follow-up.
Although the decrease in mean Oswestry disability index score was significantly greater in the single injection group (P=0.003), we found a greater improvement in the multiple injection group for the SF-36 general health subscale (P=0.02).
For both groups combined the mean Oswestry disability index score at baseline was 40.0 and at one year follow-up was 22.2 (difference 17.79, 95% confidence interval 16.47 to 19.11, P<0.001).
In the aggregate cohort there were statistically significant differences between the two treatment groups for baseline characteristics such as age, life partner, educational level, body mass index, American Society of Anesthesiologists grade, mean baseline Oswestry disability index score, and mean baseline EQ-5D score.
At baseline, the mean (SD) DAS28 was 4.9 (1.0), consistent with moderately high disease-activity, and the mean (SD) HAQ disability index was 0.9 (0.5), corresponding to mild-to-moderate disability.
The mean change Oswestry disability index score from baseline to two year follow-up was 20.8 (95% confidence interval 16.4 to 25.2) in the surgery group and 12.4 (8.5 to 16.3) in the rehabilitation group (table 3).
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