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A measure of the mean diffusivity in a voxel is the apparent diffusion coefficient (ADC).
This study also included diffusion imaging and found associated changes in mean diffusivity in the caudate of presymptomatic mutation carriers.
In addition to disease-specific findings, the data presented here suggest the persistence of the relationship between levels of myelination and corresponding diffusion-weighted MRI-derived tract fractional anisotropy and mean diffusivity in post-mortem fixed tissue (Fig. 5), supporting previous findings from studies of unfixed multiple sclerosis brain slices (Schmierer et al., 2007).
More recently, we reported higher mean diffusivity in the posterior CC (isthmus), increased radial diffusivity in the rostral body, and lower FA in the splenium of cocaine-dependent subjects relative to controls [30].
Their DTI results, like ours, showed a widespread increase in mean diffusivity in symptomatic mutation carriers and a contrasting decrease in mean diffusivity in the presymptomatic mutation carriers.
Patients with high mean diffusivity in the left superior frontal white matter showed worse performance.
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In conclusion, our results suggest that the increase in mean diffusivity found in different brain regions reflect the process of cytotoxic edema in vivo.
Additionally, patients showed significant cortical atrophy (thickness and volume) especially in the enthorhinal and temporal areas, and a significant increase in Mean Diffusivity (MD) in the hippocampus, amygdala and temporal areas, Figure 1.
More recently, changes in diffusion metrics (decrease in fractional anisotropy, increase in mean diffusivity or decrease in axial diffusivity) were reported in the tegmentum of the midbrain and rostral pons in patients with idiopathic RBD (Scherfler et al., 2010; Unger et al., 2010).
Although still an area of extensive research, mean diffusivity increases in grey matter in both healthy and diseased brains is believed to reflect the enlargement of extracellular space that is mainly associated with neuronal loss (Kantarci et al., 2005; Carlesimo et al., 2010).
We observed parallel changes in volume and reciprocal mean diffusivity alterations in two nodes of the affected frontostriatal circuits in Tourette syndrome (e.g. orbitofrontal cortex, somatosensory cortex).
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