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Indeed, a clinical relevant variation was observed for all functional scales by the QLQ-C30, with mean difference superior to 10 points in ten scales and superior to 5 points for all scales.
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Solid line mean difference.
SMD: Standardized mean difference.
WMD: Weighted mean difference.
This can mean differences in communication style.
The mean average change in BCVA from baseline to month 1 through 12 (primary end point) was statistically superior with ranibizumab (7.8 letters) compared with sham (−0.1 letters) (least squares means difference 7.9 letters; P < 0.0001).
In a post hoc multiple linear regressions of cortical thickness in these three parcellations, adjusted for age and sex, thickness was only reduced in the right superior temporal parcellation (mean difference between patients and control subjects = −.0751 mm; 95% CI −.1363 to −.0139; p =.017).
Both methods captured more contacts than a pre-study questionnaire, but ascertainment using the paper diary was superior to the PDA (mean difference: 4.52 (95% CI 0.28, 8.77).
FDR-corrected analysis showed a reduction in right superior temporal area in patients (mean difference between patients and control subjects = −206.74 mm; 95% CI −354.87 to −58.62); p =.028).
Results: Donepezil at 5 and 10mg/day was significantly superior to placebo on both the MMSE (5mg: mean difference, 3.8; 95% confidence interval [CI], 2.3-5.3; p < 0.001; 10 mg: mean difference, 2.4; 95% CI, 0.9-3.9; p = 0.001) and CIBIC-plus (p < 0.001 for each); 3mg/day was significantly superior to placebo on CIBIC-plus (p < 0.001), but not on the MMSE (p = 0.017).
HbA1c decreased by 0.94% with detemir and by 0.72% with NPH during the trial; glycaemic control was superior with detemir after 24 months, with a mean difference (detemir NPH) of −0.22% points (Table 3).
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