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In this work the effects of microspheres mean diameter, polydispersity, and polymer degradation on drug release rate from poly(lactide-co-glycolide) (PLG) microspheres are described.
Thus, our building blocks comprise populations that differ by microsphere mean diameter, polydispersity, and polymer molecular weight, giving three separate parameters that effect drug release rate, and from which we build a foundation for our tailored release.
Correlation of the n-average mean diameter, polydispersity, ζ-potential and the presence of aminophospholipid on liposome surface (in those preparations which contain phosphatidylethanolamine (PE) and phosphatidylserine (PS)) led to the conclusion that liposomes that mimicked the composition of platelets were the most stable.
Statistical design of experiments was utilized for a systematic evaluation of the influence of variations of the relative amounts of the components of the vesicle membrane (Span 60, cholesterol and SolulanC24) on vesicle mean diameter, polydispersity index and drug entrapment efficiency, chosen as the responses to optimize.
In order to confirm the dispersibility of GO materials in aqueous solution, we measured their mean diameter, polydispersity index (Pdi) and zeta potential by dynamic light scattering (DLS), and found that nGO and nrGO in water had a stable diameter (Additional file 1: Figure S1A) and Zeta potential (Additional file 1: Figure S1B) as well as Pdi (Additional file 1: Figure S1C) for 2 months.
Similar(55)
Subsequently, the average diameter, polydispersity index (PDI), zeta potential, and encapsulation efficiency of TQ-NLC were again evaluated.
The obtained homogenous suspensions were examined to determine the mean diameter and polydispersity index.
Secondly, the influence of the PVA concentration (2.5% to 5%) on the particle mean diameter and polydispersity index [PDI] was studied.
The Box Behnken design was used to study the effect of the formulation variables on the particle mean diameter (PMD), polydispersity index (PDI), zeta-potential, percent drug encapsulation efficiency (EE%), and ratio between NP size before and after freeze-drying (Sf/Si).
A 23 factorial design was used to optimize the effect of three formulation variables [amounts of Fur (X1), poly(lactic-co-glycolic acid) (X2) and poly-ɛ-caprolactone-polyethylene glycol (X3)] on particle mean diameter (Y1), polydispersity index (PDI, Y2), and percent drug encapsulation efficiency (EE%, Y3).
The mean diameter and polydispersity index were then determined using a Malvern Zetasizer® Nano Serie DTS 1060 (Malvern Instruments S.A., Worcestershire, UK).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com