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Main outcome measures The primary outcome measure was the mean daytime symptom score over seven days.
The primary outcome measure was mean daytime symptom score over seven days according to the paediatric asthma diary 18 (table 1).
When looking at single domains of asthma control, mean daytime symptom score was significantly lower in the extrafine pMDI group as compared to the DPI group (p = 0.012), demonstrating better symptom control in patients using extrafine pMDI.
The mean daytime symptom score was 15% lower in episodes treated with prednisolone than in those treated with placebo (geometric mean ratio 0.85, 95% CI 0.74 to 0.98; P=0.023).
We conducted a log scale sample size calculation 19 to determine how many episodes of acute asthma would be required to detect a 20% reduction in the mean daytime symptom score, basing the anticipated mean and variance of the daytime symptom score on previous publications 18 and using an alpha value of 0.05 with a power value of 0.9.
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In participants who contributed more than two episodes, treatment with prednisolone was associated with a 15% reduction in the daytime symptom score (ratio of geometric means 0.85, 95% CI 0.73 to 0.99) and an odds ratio for health resource use of 0.55 (95% CI 0.31 to 1.00).
Among participants who contributed two or fewer episodes, treatment with prednisolone was associated with an 18% reduction in the daytime symptom score (ratio of geometric means 0.82, 95% CI 0.63 to 1.09) and an odds ratio for health resource use of 0.53 (95% CI 0.25 to 1.10).
Secondary outcome measures were the mean night time symptom score, health resource use, asthma-free days (daytime symptom score of zero), days of school missed, days of work missed by the parent(s), and substitution of the study medication with an oral corticosteroid following a medical review.
The daytime symptom score and night time symptom score were analysed in a log scale, with comparisons reported as geometric mean ratios.
Fatigue is the cardinal daytime symptom of insomnia.
The mean daytime duration of NIV use: 5 6 h/day.
Related(15)
mean daily symptom
mean daytime pain
mean daytime cooling
mean daytime ambulatory
mean daytime water-use
mean daytime duration
mean daytime total
mean daytime glucose
mean daytime sleepiness
mean daytime light
mean daytime maximum
mean daytime temperature
mean daytime response
mean daytime glycaemia
mean daytime windspeed
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