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Mean daily basal insulin dose was significantly lower by 11% with IDeg 200 units/mL compared with IGlar.
At the end of treatment, the IDeg/IDet ratio of the mean daily basal insulin dose (U/kg) was 0.87.
At baseline, the mean daily basal insulin dose was similar with IDeg (0.33 U/kg) and IDet (0.32 U/kg) and at the end of treatment, the mean daily basal insulin dose was 0.36 and 0.41 U/kg with IDeg and IDet, respectively (Table 2).
29 Small increases in mean daily basal insulin dose was also observed from pretrial to end of trial for IDeg (A) (from 29 ± 12 units to 30 ± 13 units) and IGlar (from 23 ± 11 units to 26 ± 13 units).
The mean daily basal insulin dose, the total daily bolus insulin doses and the total insulin dose were numerically lower in the IDeg group than in the IDet group.
Small increases in mean daily basal insulin dose were observed from pretrial to end of trial for IDeg(A) (from 29 ± 12 to 30 ± 13 units) and IGlar (from 23 ± 11 to 26 ± 13 units).
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This noninferiority study design was based on the hypothesis that the difference in mean daily BG between basal plus and basal-bolus would be no greater than 18 mg/dL (1 mmol/L) (9, 10).
This was a noninferiority study design based on the hypothesis that the difference in mean daily BG between basal plus sitagliptin and basal bolus regimens would be no greater than 18 mg/dL (1 mmol/L) (11, 14).
In the analysis of studies using once-daily dosing, the mean difference in daily basal insulin dose was 0.067 units/kg (95% CI 0.05 0.09) (P < 0.001) in favor of insulin ILPS, with low heterogeneity (I = 21%).
The clinical characteristics of these 32 participants are shown in Table 1.> -wrap-foot> Data for continuous variables are means ± SD At the start of the trial, the mean total daily dose of insulin was 32.7 ± 12.4 U/day, the mean daily dose of basal insulin was 12.1 ± 5.9 U/day, and the mean daily dose of bolus insulin was 20.9 ± 8.8 U/day.
The mean daily total insulin doses (basal plus prandial insulin) by the endpoint of the study were 89 ± 66 IU for the insulin glargine group and 92 ± 66 IU for the NPH insulin group.Frequencies of the three defined categories of hypoglycaemia in this study are shown in Table 2.
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