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Costs associated with mechanical ventilation showed a similar picture, with mean costs estimated as €3,080 (mean, 8.3 days) for the on-demand group and €4,360 (mean, 12 days; P = 0.004) for the planned group (mean cost difference, €1,280).
Table 5 shows that when controlling for baseline direct cost and patients and disease characteristics, direct mean costs differed by country (P < 0.0001) irrespective of the treatment initiated, and that the mean cost difference between treatments varied by country (P < 0.0001).
When baseline direct cost and patients' and disease characteristics were controlled for, mean direct costs differed by country (P < 0.0001), irrespective of treatment initiated, and the mean cost difference between treatments varied by country (P < 0.0001).
Results from the subgroup analysis revealed a mean cost difference of £1362 (bootstrapped 95% CI, −781 to 3612) from the NHS perspective and £3506 (bootstrapped 95% CI, −2704 to 9611) from the wider societal perspective.
This resulted in a mean cost difference of $41.67 PMPM.
The mean cost difference between the groups will also be assessed using a non-parametric bootstrap.
Similar(28)
This paper provides a novel review of the analytical approaches to evaluating mean resource use and costs and mean cost differences employed in both areas, with a particular focus on their applicability to mean cost differences estimated in randomised trials.
Mean cost differences, parametric 95%% CIs, and t-tests were used when comparing costs between subgroups.
The approximate bootstrap confidence algorithm was used to estimate the 95% confidence intervals around the mean cost differences.
Due to the skew in the cost data, a sensitivity analysis was conducted assessing mean cost differences using a propensity-score stratified, bootstrap resampling approach.
To estimate the uncertainty around the ICER and ICUR, we will calculate 95% confidence intervals around the mean cost differences using the non-parametric confidence interval.
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