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This mean correlation network was used for ranking isoforms.
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Thus, the mean adjacency is roughly equal to the mean correlation in sample networks.
To validate the network regulations, we used the mean correlation across all the edges (in the network) as a statistic [ 19] and performed 5000 node label permutations.
Using the mummichug program (Li et al., 2013), we were able to identify enriched metabolic pathways in groups of metabolites not only whose mean values changed with diet, but also whose correlation network changed with diet (Fig. 3).
It will therefore also be interesting to compare our entropy metric to other network metrics that quantify randomness or to metrics that combine randomness and changes in mean correlation levels.
OnlyTr1 correlation network.
Tr1&Tr2 correlation network.
Weighted correlation network analysis (WGCNA).
(A ) Correlation network of genetic interaction profiles.
Global sncRNA – mRNA positive correlation network.
The red line shows the mean correlation.
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