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Three-stage hierarchical population pharmacokinetic modeling yielded a geometric mean clearance of 8.28 liters/h (between-patient variability, 32.3%), a volume of the central compartment of 71.4 liters (24.0%), and a volume of the peripheral compartment of 27.9 liters (35.7%).
The mean clearance of gentamicin due to CVVHDF was 2.3 ± 0.3 l/hour (82.1 ± 11.3% of total body clearance (TBC)).
Mean clearance of temsirolimus decreased from 5.72 to 5.14 l h−1 (approximately 10%), but this decrease was not manifested as changes in mean Cmax and AUC.
The mean clearance of approximately 40 ml.kg-1.h-1 noted in the non-compartmental analysis was almost identical to that seen in the population pharmacokinetics analysis.
In trauma patients with severe bleeding, the mean clearance of recombinant factor VIIa is 40 ml.kg-1.h-1 and its terminal half-life 2.4 hours.
In trauma patients with severe bleeding, the mean clearance of rFVIIa was 40 ml.kg-1.h-1 and its terminal half-life 2.4 hours.
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The term "complete response" means clearance of KS lesions on later visits when compared with the first lesions on admission.
HP results in a mean clearance rate of PQ in plasma of 73 ± 15%.
According to our results, the mean clearance rate of PQ treated with HP was 73 ± 15%.
Based on the PQ concentrations before and after HP treatment, the mean clearance rate of PQ calculated was 73 ± 15%.
The estimated mean clearance and volume of distribution of IL-6 were 0.6 L/h and 0.12 L/kg, respectively, for the mean IL-6 profile (Table 2).
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