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Things change, the mean changes with it.
The results are expressed as mean changes with 95% CIs.
The data are presented as adjusted mean changes from baseline obtained after controlling for the covariates (least-squares mean changes) with standard errors.
For the meta-analysis, data on number of subjects and mean changes with corresponding SDs in the intervention and control arm were extracted.
Efficacy data and liver enzymes were evaluated using last observation carried forward (LOCF) changes from baseline to end point with median changes by quartile and mean changes with 95% confidence intervals (CIs) calculated by quartile and for the ITT population.
Average weight gain was 7.6 ± 2.1 kg and comprised 4.2 ± 1.4 kg FM (55%) and 3.4 ± 1.5 kg FFM (45%); BMI rose more than two units (Table 1 and Fig. 1 B ). Mean changes with overfeeding are shown in Table 1.
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LPS induced significantly lower pressure pain thresholds as compared to placebo (mean change with the 0.8 ng/kg dose being −64 ± 30 kPa P = .04; with the 0.6 ng/kg dose −58 ± 55 kPa, P < .01, compared to before injection), whereas heat and cold pain thresholds remained unaffected (P's > .70).70
Last Observation Carried Forward LS Mean Change with no adjustments for number of tests conducted.
Between-group comparisons were presented as mean change with 95% CIs.
All trials further reported mean change with 95% confidence intervals (CI) in BCVA from baseline at months 1 and 3 for the actively and sham-treated populations.
The primary and continuous key secondary and exploratory end points were evaluated using ANCOVA, with treatment as the fixed effect and baseline value as the covariate, to derive a least squares estimate of the treatment difference in mean change with corresponding two-sided 95% CI.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com