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Statistically significant mean changes were observed in some laboratory analytes.
Thus, median rather than mean changes were calculated.
Interestingly, the mean changes were greater for free PSA than total PSA rises (P<0.05).
In this category, mean changes were negative, and the SRMs varied between 0.29 and 0.44.
The LS mean changes were +3.1 and +5.3 units for lixisenatide and placebo groups, respectively.
All mean changes were significant at the 0.01 level (2-tailed t test) except OKS-FCS.
Similar(20)
Population mean changes are difficult to use in clinical practice.
The exponentiated difference in log mean changes was 0.974 (90% CI 0.956 to 0.993) reflecting proportionally smaller average gap area.
In Figure 1 and Figure 2 the actual, predicted and recalled mean changes are presented.
In addition, the difference in mean changes was small in both cases of statistical significance.
These mean changes are consistent with those observed in acute-phase, placebo controlled studies of duloxetine (40 120 mg/d) [ 32].
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