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The study objectives are following: Assessing baseline adjusted between-group mean change between NAC and placebo group from baseline up till week 20 on The Montgomery Asberg Depression Rating Scale score (MADRS) (Montgomery and Åsberg 1979).
Effect size is the mean change between groups divided by the baseline standard deviation.
The mean change between the groups was 0.09 (−0.07 to 0.18).
The difference in mean change between groups was 2.67 (0.65 to 4.68) students (P=0.011).
The mean change between pre- and postoperative anxiety score was −0.5 (range, −8 to +3).
The mean change between pre- and postoperative depression score was −1.5 (range, −6 to +1).
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Treatment effects refer to the difference in mean changes between the time points of the treated and untreated control groups.
We also calculated the mean changes between groups to examine the group effect.
Change over time was summarised, reporting means at baseline and mean changes between time points.
Differences between the groups in mean changes between visits were assessed using the ANOVA procedure.
Mean changes between both treatments at each evaluation were compared with ANOVA.
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