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The data were adjusted by log transformation and the mean center method.
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To focus estimates of associations at the subject level, we adjusted for between-community and between-phase exposure effects as proposed by Janes et al. (2008) by using exposures that were mean-centered across community and phase [see Supplemental Material, Regression Model, Mean Centering Method (doi 10.1289/ehp.0901407)].
In our previous work [ 16], we evaluated two methods to preprocess probe level intensities - the mean centering method and the batch DMSO control method and found the batch DMSO control method appears to perform better than mean centering method.
Expression values were normalized using the mean center columns method in the clustering software.
Most of mean centering (MCR) methods are designed to be used with data sets whose values have a normal or nearly normal distribution.
Other commonly used batch effect methods include mean centering, standardization, and ratio-based methods [ 7].
No published method has been reported for simultaneous determination of the five components of this mixture so that the results of the mean centering of ratio spectra method were compared with those of the proposed inverse least squares method.
Method (I) is the mean centering of ratio spectra spectrophotometric method (MCR) that depends on using the mean centered ratio spectra in two successive steps that eliminates the derivative steps and therefore the signal to noise ratio is enhanced.
Smaller BH value represented less beam hardening effect: (6) BH = Mean periphery − Mean center Mean center × 100.
The mean center during consecutive 2-month intervals moved northward.
For methods, center Method wherever it falls on the page.
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